{"id":3459,"date":"2025-10-22T10:56:01","date_gmt":"2025-10-22T08:56:01","guid":{"rendered":"http:\/\/tomaszostrowski.projektyibif.pl\/hpv-vaccination-as-an-adjunct-to-surgical-treatment-of-cervical-dysplasia\/"},"modified":"2025-10-22T10:56:01","modified_gmt":"2025-10-22T08:56:01","slug":"hpv-vaccination-as-an-adjunct-to-surgical-treatment-of-cervical-dysplasia","status":"publish","type":"post","link":"https:\/\/test.drtomaszostrowski.pl\/en\/hpv-vaccination-as-an-adjunct-to-surgical-treatment-of-cervical-dysplasia\/","title":{"rendered":"HPV Vaccination as an Adjunct to Surgical Treatment of Cervical Dysplasia"},"content":{"rendered":"<p>A meta-analysis of 11 studies has shown that administering a prophylactic HPV vaccine shortly before or immediately after surgical treatment of moderate to high-grade cervical dysplasia (CIN 2+) significantly reduces the risk of recurrence<a class=\"sdendnoteanc\" href=\"#sdendnote1sym\" name=\"sdendnote1anc\"><sup>1<\/sup><\/a>.<br \/>\nThe likely mechanisms explaining the beneficial effect of prophylactic HPV vaccination in women already infected with the virus include:<\/p>\n<ul>\n<li>stimulation of the cellular immune response, which may play an important role in preventing HPV recurrence<a class=\"sdendnoteanc\" href=\"#sdendnote2sym\" name=\"sdendnote2anc\"><sup>2<\/sup><\/a>,<\/li>\n<li>increased vaccine efficacy due to reduction of local inflammatory response following surgical treatment of HPV-related cervical lesions<a class=\"sdendnoteanc\" href=\"#sdendnote3sym\" name=\"sdendnote3anc\"><sup>3<\/sup><\/a><sup>,<\/sup><a class=\"sdendnoteanc\" href=\"#sdendnote4sym\" name=\"sdendnote4anc\"><sup>4<\/sup><\/a>,<\/li>\n<li>development of cross-protection against other HPV types,<sup><a class=\"sdendnoteanc\" href=\"#sdendnote5sym\" name=\"sdendnote5anc\">5<\/a>,<\/sup><a class=\"sdendnoteanc\" href=\"#sdendnote6sym\" name=\"sdendnote6anc\"><sup>6<\/sup><\/a>.<\/li>\n<\/ul>\n<p>References<\/p>\n<div id=\"sdendnote1\">\n<p class=\"sdendnote\"><a class=\"sdendnotesym\" href=\"#sdendnote1anc\" name=\"sdendnote1sym\">1<\/a> <span style=\"color: #212121;\"><span lang=\"en-US\">Di Donato V, Caruso G, Bogani G, Cavallari EN, Palaia G, Perniola G, Ralli M, Sorrenti S, Romeo U, Pernazza A, Pierangeli A, Clementi I, Mingoli A, Cassoni A, Tanzi F, Cuccu I, Recine N, Mancino P, de Vincentiis M, Valentini V, d&#8217;Ettorre G, Della Rocca C, Mastroianni CM, Antonelli G, Polimeni A, Muzii L, Palaia I. HPV Vaccination after Primary Treatment of HPV-Related Disease across Different Organ Sites: A Multidisciplinary Comprehensive Review and Meta-Analysis. Vaccines (Basel). 2022 Feb 4;10(2):239. doi: 10.3390\/vaccines10020239. PMID: 35214697; PMCID: PMC8879645.<br \/>\n<\/span><\/span><a class=\"sdendnotesym\" href=\"#sdendnote2anc\" name=\"sdendnote2sym\">2<\/a> <span style=\"color: #333333;\"><span lang=\"en-US\">Zurek Munk-Madsen, M., Toft, L., Kube, T., Richter, R., Ostergaard, L., S\u00f8gaard, O. S., \u2026 Kaufmann, A. M. (2017). Cellular immunogenicity of human papillomavirus vaccines Cervarix and Gardasil in adults with HIV infection. <\/span><\/span><span style=\"color: #333333;\"><span lang=\"en-US\"> <\/span><\/span><span style=\"color: #333333;\">Human Vaccines &#038; Immunotherapeutics<\/span><span style=\"color: #333333;\">,<\/span><span style=\"color: #333333;\"> <\/span><span style=\"color: #333333;\">14<\/span><span style=\"color: #333333;\">(4), 909\u2013916. https:\/\/doi.org\/10.1080\/21645515.2017.1407896<br \/>\n<\/span><a class=\"sdendnotesym\" href=\"#sdendnote3anc\" name=\"sdendnote3sym\">3<\/a> <span style=\"color: #212121;\"><span lang=\"en-US\">Saftlas AF, Spracklen CN, Ryckman KK, Stockdale CK, Penrose K, Ault K, Rubenstein LM, Pinto LA. Influence of a loop electrosurgical excision procedure (LEEP) on levels of cytokines in cervical secretions. J Reprod Immunol. 2015 Jun;109:74-83. doi: 10.1016\/j.jri.2015.01.002. Epub 2015 Jan 30. PMID: 25721621.<br \/>\n<\/span><\/span><a class=\"sdendnotesym\" href=\"#sdendnote4anc\" name=\"sdendnote4sym\">4<\/a> <span style=\"color: #212121;\"><span lang=\"en-US\">Frazer IH. Interaction of human papillomaviruses with the host immune system: a well evolved relationship. Virology. 2009 Feb 20;384(2):410-4. doi: 10.1016\/j.virol.2008.10.004. Epub 2008 Nov 4. PMID: 18986661.<br \/>\n<\/span><\/span><a class=\"sdendnotesym\" href=\"#sdendnote5anc\" name=\"sdendnote5sym\">5<\/a> <span style=\"color: #212121;\"><span lang=\"en-US\">Ault KA. Human papillomavirus vaccines and the potential for cross-protection between related HPV types. Gynecol Oncol. 2007 Nov;107(2 Suppl 1):S31-3. doi: 10.1016\/j.ygyno.2007.08.059. PMID: 18499916.<br \/>\n<\/span><\/span><a class=\"sdendnotesym\" href=\"#sdendnote6anc\" name=\"sdendnote6sym\">6<\/a> <span style=\"color: #212121;\"><span lang=\"en-US\">De Vincenzo R, Ricci C, Conte C, Scambia G. HPV vaccine cross-protection: Highlights on additional clinical benefit. Gynecol Oncol. 2013 Sep;130(3):642-51. doi: 10.1016\/j.ygyno.2013.05.033. Epub 2013 Jun 5. PMID: 23747835.<\/span><\/span><\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>A meta-analysis of 11 studies has shown that administering a prophylactic HPV vaccine shortly before or immediately after surgical treatment of moderate to high-grade cervical dysplasia (CIN 2+) significantly reduces the risk of recurrence.<\/p>\n","protected":false},"author":3,"featured_media":3193,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[47],"tags":[],"class_list":["post-3459","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-knowledge-zone"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.3 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>HPV Vaccination as an Adjunct to Surgical Treatment of Cervical Dysplasia | Indywidualna Specjalistyczna Praktyka Lekarska Tomasz 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